Magnetic Resonance Imaging Study of Cerebrospinal Fluid

Magnetic resonance mental imagery Study of Cerebrospinal FluidMagnetic Resonance Imaging Study of Cerebrospinal Fluid Dynamics in Congenital sensation AnomaliesProtocol of Thesis for Partial Fulfillment of Master Degree in RadiodiagnosisByEman Mahmoud Elsayed SobhM.B.B.ChRadiodiagnosis Resident Ministry of HealthSupervisorsProf. Dr. Amany Ezzat Mohammed MousaProfessor of RadiodiagnosisFaculty of MedicineMansoura UniversityDr. Mahmoud Abd Ellatif Mohammed henchman Professor of RadiodiagnosisFaculty of MedicineMansoura University2017IntroductionCongenital consciousness anomalies atomic number 18 abnormal developments of the brain that happen during intrauterine life and they are obsolete among the nonheritable anomalies of various organ systems. These anomalies of the central nervous system prepare approximately 25% of perinatal deaths and account for about 33% of every last(predicate) major anomalies diagnosed at or after birth. The etiology of congenital brain anomalies is poorly understood, albeit some clinical and experimental evidence indicates that a transmutation of factors, including genetic (chromosome abnormality), environmental (ionizing radiation, toxic agents), infection (rubella and cytomegalovirus), and nutrition (hypervitaminosis A) might drama some roles(Chen Zimmerman, 2000).It is important to diagnose these conditions as early as attainable due to its far reaching neurological deficit and detrimental outcome. roughly of the congenital brain anomalies lot be reliably diagnosed by neuroimaging (computed tomography or magnetic resonance imaging) of the brain. Radiologist and treating physician should be awake of various specific imaging appearances and unique signs of these anomalies to avoid delay in diagnosis and thereby further treatment (Singh, Srivastav, Singhania, Devi, 2014).Imaging techniques may be underutilized when clinicians are unaware of the technique or dont recognize its potential. During the last trey decades, flow-sensitive magnetic resonance imaging (MRI) techniques kick in been increasingly applied to quantitatively and qualitatively assess cerebrospinal fluid (CSF) flow dynamics in congenital brain disorders. CSF flowmetry is an extremely valuable tool because it is rapid, sensitive, non-invasive, easily performed and provides hypercritical information in preoperative appraisal as well as post-operative follow up of these patients. It is also effective in treatment think (Yildiz, Yazici, Hakyemez, Erdogan, Parlak, 2006 Zhang Li, 2012).Phase contrast MRI is one the magnetic resonance angiography techniques that have been modified to subscribe the CSF hydrodynamics. The normal and abnormal CSF hydrodynamics can be assessed quantitatively by measuring the peak velocity of CSF in the aqueduct victimisation two-dimensional signifier-contrast MRI which demonstrates mechanical coupling between cerebral rootage and CSF flow during the cardiac cycle. The normal physiologic motion of C SF is pulsatile which synchronizes with the cardiac cycle. numerical analysis of CSF flow in pathways such as aqueduct that is tubular and relatively regular in diameter is desirable because the resulting laminar flow can be measured accurately by phase-contrast MRI. Qualitative assessment provides optic appreciation of the CSF flow through the aqueduct and basal cisterns. (Giiang, Chen, Chen, Huang, Chung, 2000).Aim of WorkThe betoken of this work is to assess the CSF flow dynamics in different congenital brain anomalies using phase-contrast magnetic resonance imaging (PC MRI).PatientsSite of the study Mansoura University Hospital, Radiodiagnosis Department, MRI unitSample size 30 patientsDuration deep down 1 yearInclusion CriteriaPatients with congenital brain anomalies diagnosed clinically or radiologicallyExclusion criteriaPatients / Guardians refusing the procedurePatients have contraindications to MRI studiesPatients with associated known arrhythmiasMethodology altogethe r patients forget be subjected toFull clinical examinationRadiological investigations (MRI including phase contrast study of CSF flow dynamics)Electrocardiograph (ECG)Informed consent will be obtained from all patients after full explanation of the benefits and risks of the procedure.Any out of the blue(predicate) risks appear during the course of the research will be cleared to the participants and the honourable committee on timeAny patients will be inured in the hospital if any complications occur to them related to the technique cover and confidentiality will be maintained to all patients.ReferencesChen, C.-Y., Zimmerman, R. A. (2000). Congenital brain anomalies Neuroimaging (pp. 491-530) Springer.Giiang, L.-H., Chen, C.-Y., Chen, M.-Y., Huang, T.-Y., Chung, W. (2000). radiation pattern and abnormal cerebrospinal fluid dynamics evaluated by optimized cine phase-contrast MR imaging. Chin J Radiol, 25, 191-195.Singh, T. G., Srivastav, V., Singhania, P., Devi, S. M. (2014). Congenital brain anomalies Neuroimaging findings. Journal of Dr. NTR University of Health Sciences, 3(2), 77.Yildiz, H., Yazici, Z., Hakyemez, B., Erdogan, C., Parlak, M. (2006). Evaluation of CSF flow patterns of back end fossa cystic malformations using CSF flow MR imaging. Neuroradiology, 48(9), 595-605. doi10.1007/s00234-006-0098-8Zhang, B., Li, S. B. (2012). Cine-PC MR in assessment of cerebrospinal fluid velocity in the aqueduct of the midbrain correlated with intracranial pressureinitial study. Med Hypotheses, 78(2), 227-230. doi10.1016/j.mehy.2011.10.031